RT Journal Article
SR Electronic
T1 Second-to-fourth Digit Ratio in Systemic Lupus Erythematosus
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.140974
DO 10.3899/jrheum.140974
A1 Kentaro Doe
A1 Kazuhisa Nozawa
A1 Takuya Hirai
A1 Hiroshi Tsushima
A1 Eri Hayashi
A1 Kaori Hiruma
A1 Seiichiro Ando
A1 Soichiro Nakano
A1 Takayuki Kon
A1 Hirofumi Amano
A1 Ken Yamaji
A1 Naoto Tamura
A1 Yoshinari Takasaki
YR 2015
UL http://www.jrheum.org/content/early/2015/02/24/jrheum.140974.abstract
AB Objective Systemic lupus erythematosus (SLE) occurs predominantly in women, and sex hormones play an important role in SLE. Variation in the second-to-fourth digit ratio (2D4D ratio) is attributed to sex hormone exposure. Therefore, we evaluated the relationship between sex hormones and SLE by measuring 2D4D ratios. Methods We measured 2D4D ratios in 100 patients with SLE and 200 normal healthy controls (NHC). Results Patients with SLE had a lower 2D4D ratio than NHC. Conclusion Our study suggests that patients with SLE have experienced high prenatal testosterone and low prenatal estrogen. To our knowledge, this is the first study evaluating the association between 2D4D ratio and SLE.