TY - JOUR T1 - Second-to-fourth Digit Ratio in Systemic Lupus Erythematosus JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.140974 SP - jrheum.140974 AU - Kentaro Doe AU - Kazuhisa Nozawa AU - Takuya Hirai AU - Hiroshi Tsushima AU - Eri Hayashi AU - Kaori Hiruma AU - Seiichiro Ando AU - Soichiro Nakano AU - Takayuki Kon AU - Hirofumi Amano AU - Ken Yamaji AU - Naoto Tamura AU - Yoshinari Takasaki Y1 - 2015/03/01 UR - http://www.jrheum.org/content/early/2015/02/24/jrheum.140974.abstract N2 - Objective Systemic lupus erythematosus (SLE) occurs predominantly in women, and sex hormones play an important role in SLE. Variation in the second-to-fourth digit ratio (2D4D ratio) is attributed to sex hormone exposure. Therefore, we evaluated the relationship between sex hormones and SLE by measuring 2D4D ratios. Methods We measured 2D4D ratios in 100 patients with SLE and 200 normal healthy controls (NHC). Results Patients with SLE had a lower 2D4D ratio than NHC. Conclusion Our study suggests that patients with SLE have experienced high prenatal testosterone and low prenatal estrogen. To our knowledge, this is the first study evaluating the association between 2D4D ratio and SLE. ER -