RT Journal Article
SR Electronic
T1 Polymyositis/dermatomyositis and Malignancy Risk: A Metaanalysis Study
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.140566
DO 10.3899/jrheum.140566
A1 Zaixing Yang
A1 Feng Lin
A1 Baodong Qin
A1 Yan Liang
A1 Renqian Zhong
YR 2014
UL http://www.jrheum.org/content/early/2014/11/24/jrheum.140566.abstract
AB Objective To investigate the association between polymyositis (PM)/dermatomyositis (DM) and risks of malignancy. Methods We searched Pubmed for articles dated before August 16, 2013. Studies were included if they met the following criteria: (1) a cohort or observational study; (2) PM or DM as one of the exposures of interest; (3) cancer as an outcome of interest; and (4) the rate ratio (RR) or standardized incidence ratio (SIR) were available with their 95% CI. We used random-effects or fixed-effects models to calculate the pooled RR according to the heterogeneity test. Results Twenty publications were included. Compared with the general population, the pooled RR for patients with PM, DM, and PM/DM were 1.62 (95% CI 1.19–2.04), 5.50 (4.31–6.70), and 4.07 (3.02–5.12), respectively. The increased risks were more significant in patients within the first year of myositis diagnosis, male patients, and population-based studies (for DM). A significant association was also found between PM or DM and most site-specific malignancies. However, both PM and DM were not associated with stomach and prostate cancers. Significant heterogeneity was found between studies on association between PM/DM and overall malignancy, but not between PM/DM and the majority of site-specific malignancies, suggesting that that inherent malignancy difference may be a major source of heterogeneity. Conclusion The present metaanalysis indicates that PM and DM are significantly associated with increased risks of overall malignancy and most site-specific malignancies. The number of studies on association between PM or DM and some malignancies is too small to draw a firm conclusion. Accordingly, more research is needed for these malignancies.