RT Journal Article
SR Electronic
T1 Urate Transporters: Transforming the Face of Hyperuricemia and Gout
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.141019
DO 10.3899/jrheum.141019
A1 Michael A.  Becker
A1 Peter A.  Simkin
A1 Leif B.  Sorensen
YR 2014
UL http://www.jrheum.org/content/early/2014/08/26/jrheum.141019.abstract
AB Although some readers of The Journal may find the September article by Torres, et al a challenge, we believe the effort to persevere will be well worth it. This is because the report nicely illustrates how the burgeoning field of analysis of common variants in gene sequences (polymorphisms), when combined with scrupulous attention to the clinical characteristics of affected patients, can simplify and extend understanding of complicated disease mechanisms and, potentially, contribute to more informed clinical evaluation and management decisions. The disease at issue here is gout, an inflammatory metabolic disorder afflicting over 8 million of the estimated 40 million hyperuricemic American adults.