TY - JOUR T1 - Plasma Adipokine Levels and Their Association with Overall Burden of Painful Joints among Individuals with Hip and Knee Osteoarthritis JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.130709 SP - jrheum.130709 AU - Anthony V. Perruccio AU - Nizar N. Mahomed AU - Vinod Chandran AU - Rajiv Gandhi Y1 - 2013/12/15 UR - http://www.jrheum.org/content/early/2013/12/12/jrheum.130709.abstract N2 - Objective To investigate the association between plasma adipokine levels and the burden of painful joints among individuals with hip and knee osteoarthritis (OA). Methods Adipokines (leptin, adiponectin, adipsin, resistin) were determined by ELISA (n = 78). Individuals reported painful joints on a homunculus. Associations were examined by sex-stratified Poisson analyses. Results Adjusted for age, body mass index, and hip/knee OA, higher leptin and adiponectin and lower adipsin levels were associated with greater painful joint burden (i.e., counts) among women (p < 0.01). Among men, higher resistin levels were associated with lower counts (p = 0.03). Conclusion Findings support the likelihood of a systemic-dependent sex-specific pain burden among individuals with OA. ER -