RT Journal Article
SR Electronic
T1 Responsiveness in Rheumatoid Arthritis. A Report from the OMERACT 11 Ultrasound Workshop
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.131084
DO 10.3899/jrheum.131084
A1 Annamaria Iagnocco
A1 Esperanza Naredo
A1 Richard Wakefield
A1 George A.W.  Bruyn
A1 Paz Collado
A1 Sandrine Jousse-Joulin
A1 Stephanie Finzel
A1 Sarah Ohrndorf
A1 Andrea  Delle Sedie
A1 Marina Backhaus
A1 Hilde Berner-Hammer
A1 Frederique Gandjbakhch
A1 Gurjit Kaeley
A1 Damien Loeuille
A1 Ingrid Moller
A1 Lene Terslev
A1 Philippe Aegerter
A1 Sibel Aydin
A1 Peter V.  Balint
A1 Emilio Filippucci
A1 Peter Mandl
A1 Carlos Pineda
A1 Johannes Roth
A1 Silvia Magni-Manzoni
A1 Niolay Tzaribachev
A1 Wolfgang A.  Schmidt
A1 Philip G.  Conaghan
A1 Maria-Antonietta D'Agostino
YR 2013
UL http://www.jrheum.org/content/early/2013/11/13/jrheum.131084.abstract
AB Objective To summarize the work performed by the Outcome Measures in Rheumatology (OMERACT) Ultrasound (US) Task Force on the validity of different US measures in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) presented during the OMERACT 11 Workshop. Methods The Task Force is an international group aiming to iteratively improve the role of US in arthritis clinical trials. Recently a major focus of the group has been the assessment of responsiveness of a person-level US synovitis score in RA: the US Global Synovitis Score (US-GLOSS) combines synovial hypertrophy and power Doppler signal in a composite score detected at joint level. Work has also commenced examining assessment of tenosynovitis in RA and the role of US in JIA. Results The US-GLOSS was tested in a large RA cohort treated with biologic therapy. It showed early signs of improvement in synovitis starting at Day 7 and increasing to Month 6, and demonstrated sensitivity to change of the proposed grading. Subsequent voting questions concerning the application of the US-GLOSS were endorsed by > 80% of OMERACT delegates. A standardized US scoring system for detecting and grading severity of RA tenosynovitis and tendon damage has been developed, and acceptable reliability data were presented from a series of exercises. A preliminary consensus definition of US synovitis in pediatric arthritis has been developed and requires further testing. Conclusion At OMERACT 11, consensus was achieved on the application of the US-GLOSS for evaluating synovitis in RA; and work continues on development of RA tenosynovitis scales as well as in JIA synovitis.