@article {Smithjrheum.130528, author = {Vanessa Smith and Valeria Riccieri and Carmen Pizzorni and Saskia Decuman and Ellen Deschepper and Carolien Bonroy and Alberto Sulli and Yves Piette and Filip De Keyser and Maurizio Cutolo}, title = {Nailfold Capillaroscopy for Prediction of Novel Future Severe Organ Involvement in Systemic Sclerosis}, elocation-id = {jrheum.130528}, year = {2013}, doi = {10.3899/jrheum.130528}, publisher = {The Journal of Rheumatology}, abstract = {Objective Assessment of associations of nailfold videocapillaroscopy (NVC) scleroderma (systemic sclerosis; SSc) ({\textquotedblleft}early,{\textquotedblright} {\textquotedblleft}active,{\textquotedblright} and {\textquotedblleft}late{\textquotedblright}) with novel future severe clinical involvement in 2 independent cohorts. Methods Sixty-six consecutive Belgian and 82 Italian patients with SSc underwent NVC at baseline. Images were blindly assessed and classified into normal, early, active, or late NVC pattern. Clinical evaluation was performed for 9 organ systems (general, peripheral vascular, skin, joint, muscle, gastrointestinal tract, lung, heart, and kidney) according to the Medsger disease severity scale (DSS) at baseline and in the future (18{\textendash}24 months of followup). Severe clinical involvement was defined as category 2 to 4 per organ of the DSS. Logistic regression analysis (continuous NVC predictor variable) was performed. Results The OR to develop novel future severe organ involvement was stronger according to more severe NVC patterns and similar in both cohorts. In simple logistic regression analysis the OR in the Belgian/Italian cohort was 2.16 (95\% CI 1.19{\textendash}4.47, p = 0.010)/2.33 (95\% CI 1.36{\textendash}4.22, p = 0.002) for the early NVC SSc pattern, 4.68/5.42 for the active pattern, and 10.14/12.63 for the late pattern versus the normal pattern. In multiple logistic regression analysis, adjusting for disease duration, subset, and vasoactive medication, the OR was 2.99 (95\% CI 1.31{\textendash}8.82, p = 0.007)/1.88 (95\% CI 1.00{\textendash}3.71, p = 0.050) for the early NVC SSc pattern, 8.93/3.54 for the active pattern, and 26.69/6.66 for the late pattern versus the normal pattern. Conclusion Capillaroscopy may be predictive of novel future severe organ involvement in SSc, as attested by 2 independent cohorts.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2013/10/09/jrheum.130528}, eprint = {https://www.jrheum.org/content/early/2013/10/09/jrheum.130528.full.pdf}, journal = {The Journal of Rheumatology} }