RT Journal Article
SR Electronic
T1 Joint Effects of Alcohol Consumption and <em>ABCG2</em> Q141K on Chronic Tophaceous Gout Risk
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.130870
DO 10.3899/jrheum.130870
A1 Hung-Pin Tu
A1 Albert Min-Shan  Ko
A1 Shang-Lun Chiang
A1 Su-Shin Lee
A1 Han-Ming Lai
A1 Chia-Min Chung
A1 Chung-Ming Huang
A1 Chien-Hung Lee
A1 Tzer-Min Kuo
A1 Mei-Jung Hsieh
A1 Ying-Chin Ko
YR 2014
UL http://www.jrheum.org/content/early/2014/02/12/jrheum.130870.abstract
AB Objective To investigate the joint effects of alcohol consumption and ABCG2 gene variants on tophaceous gout occurrence. Methods The V12M (rs2231137), Q126X (rs72552713), and Q141K (rs2231142) of the ABCG2 gene were genotyped among controls, nontophaceous, and tophaceous gout cases in Taiwanese Han (n = 446, 77, 177) and Taiwan Aborigines (n = 1105, 203, 330). Results The missense variations V12M (C) and Q141K (T) significantly associated with tophaceous gout (p trend = 4.08 × 10-2, 9.00 × 10-12 in Han; 1.81 × 10-3, 9.34 × 10-10 in Aborigines). The nonsense variation Q126X (T) exerted a significant effect only in Han (p = 1.10 × 10-2), but not in Aborigines. In the prediction of tophaceous gout, the Q141K (T) OR were 1.51 in Han, 1.50 in Aborigines, and 1.55 (p = 7.84 × 10-5) in pooled analysis when compared to nontophaceous gout. We found the joint effects of alcohol consumption and Q141K (T/T) highly associated with tophaceous gout (adjusted OR ≥ 5.11; p ≤ 7.78 × 10-4); specifically the ever drinkers carrying the Q141K (T/T; adjusted OR 25.05, p = 9.21 × 10-4 in Han; adjusted OR 14.87, p = 1.08 × 10-8 in Aborigines). Conclusion Our findings showed alcohol consumption and Q141K, independently and jointly, associated with the risk of chronic tophaceous gout.