RT Journal Article
SR Electronic
T1 Minor Salivary Gland Inflammatory Lesions in Sjögren Syndrome: Do They Evolve?
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.130256
DO 10.3899/jrheum.130256
A1 Efstathia K.  Kapsogeorgou
A1 Maria I.  Christodoulou
A1 Demosthenes B.  Panagiotakos
A1 Spyros Paikos
A1 Anna Tassidou
A1 Athanasios G.  Tzioufas
A1 Haralampos M.  Moutsopoulos
YR 2013
UL http://www.jrheum.org/content/early/2013/07/23/jrheum.130256.abstract
AB Objective The lymphocytic infiltrates of minor salivary gland (MSG) lesions of Sjögren syndrome (SS) vary in grade and composition and are generally thought to develop in stepwise manner. Their progression over time is not well defined. Methods We studied repetitive MSG biopsy specimens from 28 patients with primary SS. Results The infiltration grade and prevalence of the major infiltrating cell types (T and B cells, macrophages, dendritic cells, natural killer cells) remained largely unchanged during a median 55 month biopsy time interval followup (quartiles 42–81). Conclusion We found significant disease progression involving the development of mucosa-associated lymphoid tissue lymphoma in patients expressing adverse serologic prognostic factors, such as low serum C4 complement levels and cryoglobulinemia.