PT  - JOURNAL ARTICLE
AU  - Roberta Priori
AU  - Angelica Gattamelata
AU  - Mariagrazia Modesti
AU  - Serena Colafrancesco
AU  - Silvia Frisenda
AU  - Antonina Minniti
AU  - Marialuisa Framarino-dei-Malatesta
AU  - Marta Maset
AU  - Luca Quartuccio
AU  - Salvatore  De Vita
AU  - Elena Bartoloni
AU  - Alessia Alunno
AU  - Roberto Gerli
AU  - Francesca Strigini
AU  - Chiara Baldini
AU  - Chiara Tani
AU  - Marta Mosca
AU  - Stefano Bombardieri
AU  - Guido Valesini
TI  - Outcome of Pregnancy in Italian Patients with Primary Sjögren Syndrome
AID  - 10.3899/jrheum.121518
DP  - 2013 Jun 01
TA  - The Journal of Rheumatology
PG  - jrheum.121518
4099  - http://www.jrheum.org/content/early/2013/05/29/jrheum.121518.short
4100  - http://www.jrheum.org/content/early/2013/05/29/jrheum.121518.full
AB  - Objective To investigate pregnancy and fetal outcomes in patients with primary Sjögren syndrome (pSS). Methods An obstetric history of 36 women with established diagnosis of pSS at pregnancy was obtained from a multicenter cohort of 1075 patients. In a subgroup case-control analysis, 12 deliveries in patients with pSS were compared with 96 control deliveries. Results Thirty-six women (31 with anti-SSA/Ro and/or anti-SSB/La antibodies) with an established diagnosis of pSS had 45 pregnancies with the delivery of 40 newborns. Two miscarriages, 2 fetal deaths, and 1 induced abortion were recorded. Mean age at the first pregnancy was 33.9 years; mean number of pregnancies was 1.25; 18/40 (45%) cesarean births were delivered; mean pregnancy length was 38.5 weeks (range 32–43), with 6 preterm deliveries. The mean Apgar score at 5 min was 8.9, mean birthweight was 2920 g (range 826–4060 g). Congenital heart block (CHB) occurred in 2/40 (5%) newborns. The reported rate of breastfeeding for at least 1 month was 60.5%. In 4/40 pregnancies (10%) a flare of disease activity was observed within a year from delivery. In the case-control subgroup analysis, 12 deliveries were compared with 96 controls and no significant differences were found. Conclusion Patients with pSS can have successful pregnancies, which might be followed by a mild relapse. CHB was the only cause of death for offspring of mothers with pSS.