PT  - JOURNAL ARTICLE
AU  - Syed Fazal  Jalil
AU  - Attya Bhatti
AU  - F. Yesim  Demirci
AU  - Xingbin Wang
AU  - Iltaf Ahmed
AU  - Mushtaq Ahmed
AU  - M. Michael  Barmada
AU  - Javaid M.  Malik
AU  - Peter John
AU  - M. Ilyas  Kamboh
TI  - Replication of European Rheumatoid Arthritis Loci in a Pakistani Population
AID  - 10.3899/jrheum.121050
DP  - 2013 Feb 01
TA  - The Journal of Rheumatology
PG  - jrheum.121050
4099  - http://www.jrheum.org/content/early/2013/01/27/jrheum.121050.short
4100  - http://www.jrheum.org/content/early/2013/01/27/jrheum.121050.full
AB  - Objective Genetic studies have identified several rheumatoid arthritis (RA) susceptibility loci in European-derived populations. The same biological pathways may be involved in determining the RA risk in different population groups. We sought to replicate the association of 33 single-nucleotide polymorphisms (SNP) from 31 RA susceptibility loci confirmed among Europeans in a unique Pakistani population. Methods We genotyped 33 SNP in a sample of 366 Pakistanis that comprised related and unrelated cases and controls. Genotyping was performed using TaqMan assays and the results were analyzed with family case-control software. Results Twelve of the 33 SNP were replicated in this sample with significant p values ranging from 7.05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP. Conclusion Our observations suggest that a number of RA susceptibility loci and related pathways are shared across different populations.