TY - JOUR T1 - Evaluation of Clinical Measures and Different Criteria for Diagnosis of Adult-onset Still's Disease in a Chinese Population JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.100766 SP - jrheum.100766 AU - Lindi Jiang AU - Zhen Wang AU - Xiaomin Dai AU - Xuejuan Jin Y1 - 2011/02/01 UR - http://www.jrheum.org/content/early/2011/01/27/jrheum.100766.abstract N2 - Objective To determine the value of clinical measures in diagnosis of adult-onset Still’s disease (AOSD), and to identify the optimal set of proposed classification criteria, in a Chinese population. Methods A total of 70 patients with AOSD and 140 non-AOSD inpatients with fever were retrospectively identified at Zhongshan Hospital, Shanghai, from January 2003 to December 2009. Clinical measures and 4 sets of diagnostic criteria (Yamaguchi, Calabro, Cush, and Reginato) were evaluated by sensitivity, specificity, positive/negative predictive value (PPV, NPV), and positive/negative likelihood ratio (PLR, NLR) for diagnosis of AOSD. Results In our series, higher sensitivity included hyperpyrexia (temperature ≥ 39°C, 94.29%), arthralgia (80.0%), polymorphonuclear neutrophils (PMN) ≥ 75% (84.29%), serum ferritin ≥ 2-fold the upper normal value (90.0%), negative antinuclear antibodies (85.29%), and rheumatoid factor (84.38%); while higher specificity included transient erythema (98.57%), sore throat (85.0%), leukocytes ≥ 15,000/mm3 (87.86%), and PMN ≥ 85% (85.0%). Rash, arthralgia, and sore throat were found to have better sensitivity and specificity (PLR 3.29–4.86). Leukocytes ≥ 10,000/mm3, PMN ≥ 80%, and serum ferritin ≥ 5-fold the upper normal limit were set as critical points. The Reginato criteria set had the highest specificity, 99.29%. The Yamaguchi set had the highest sensitivity, 78.57%, with a better accuracy of 87.14%. Conclusion The Yamaguchi diagnostic criteria had better accuracy in Chinese patients. Indicators such as rash, arthralgia, sore throat, leukocytes ≥ 10,000/mm3, PMN ≥ 80%, and serum ferritin ≥ 5-fold the upper normal limit were helpful for diagnosis of AOSD. We recommend using these indicators in combination instead of alone. ER -