RT Journal Article
SR Electronic
T1 Antinuclear Antibodies and Clinical Associations in a British Cohort with Limited Cutaneous Systemic Sclerosis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.100754
DO 10.3899/jrheum.100754
A1 Angela E. Gliddon
A1 Caroline J. Doré
A1 Juliet Dunphy
A1 Zoë Betteridge
A1 Neil J. McHugh
A1 Peter J. Maddison
YR 2011
UL http://www.jrheum.org/content/early/2011/01/11/jrheum.100754.abstract
AB Objective To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (lcSSc). Methods Sera from 180 patients with lcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies. Results SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at lcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis. Conclusion The majority of patients with lcSSc belong to distinctive serologic subsets, potentially with prognostic significance.