RT Journal Article
SR Electronic
T1 Cortisol During the Day in Patients with Systemic Lupus Erythematosus or Primary Sjögren's Syndrome
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.100572
DO 10.3899/jrheum.100572
A1 Marlies C. van der Goes
A1 Ercolie R. Bossema
A1 André Hartkamp
A1 Guido L.R. Godaert
A1 Johannes W.G. Jacobs
A1 Aike A. Kruize
A1 Ronald H.W.M. Derksen
A1 Johannes W.J. Bijlsma
A1 Rinie Geenen
YR 2010
UL http://www.jrheum.org/content/early/2010/12/12/jrheum.100572.abstract
AB Objective To compare the level and change of cortisol during the day of patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) with low and high erythrocyte sedimentation rate (ESR). Methods Saliva was collected in the real-life environment of 21 women with SLE, 16 women with pSS, and 30 age-matched healthy women at 9 fixed timepoints during 2 consecutive days. Repeated measures ANOVA was performed to examine whether cortisol levels during the day were different for the patients with low ESR (≤ 20 mm/h) versus those with high ESR (> 20 mm/h). Results The groups with low and high ESR showed the characteristic change of cortisol during the day (time-of-day effect, F = 124.9, p < 0.001). The cortisol awakening level was lower for patients with high ESR than for patients with low ESR (group*time effect, F = 3.1, p = 0.02). Conclusion The cortisol awakening level differs for patients with low and high ESR, which indicates the usefulness of further studies of hypothalamic-pituitary-adrenal axis dynamics in patients with SLE and pSS.