TY - JOUR T1 - Healthcare Cost and Loss of Productivity in a Canadian Population of Patients with and without Lupus Nephritis JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.100482 SP - jrheum.100482 AU - Elaheh Aghdassi AU - Wendy Zhang AU - Yvan St-Pierre AU - Ann E. Clarke AU - Stacey Morrison AU - Valentina Peeva AU - Carolina Landolt-Marticorena AU - Jiandong Su AU - Heather Reich AU - James Scholey AU - Andrew Herzenberg AU - Janet E. Pope AU - Christine Peschken AU - Joan E. Wither AU - Paul R. Fortin Y1 - 2010/12/15 UR - http://www.jrheum.org/content/early/2010/12/12/jrheum.100482.abstract N2 - Objective To compare the healthcare cost and loss of productivity in patients with systemic lupus erythematosus (SLE) with (LN) and without lupus nephritis (lupus nephritis-negative, LNN). Methods Patients were classified into those with active (ALN and ALNN) and inactive disease (ILN and ILNN). Patients reported on visits to healthcare professionals and use of diagnostic tests, medications, assistive devices, alternative treatments, hospital emergency visits, surgical procedures, and hospitalizations as well as loss of productivity in the 4 weeks preceding enrollment. Results Enrollment was 141 patients, 79 with LN and 62 LNN. Patients with LN were more likely to visit rheumatologists and nephrologists, undergo diagnostic tests, and had higher costs for medications than patients who were LNN. The annual healthcare cost averaged $CAN 12,597 ± 9946 for patients with LN and $10,585 ± 13,149 for patients who were LNN, a difference of $2012 (95% CI –$2075, $6100). Patients with ALN had more diagnostic tests and surgical procedures, contributing to a significantly higher annual direct cost ($14,224 ± 10,265) compared to patients with ILN ($9142 ± 8419) and a difference of $5082 (95% CI $591, $9573). The healthcare cost was not different between patients with ALNN and patients with ILNN. In patients with LN and patients who were LNN, < 50% were employed and on average missed 6.5–9 days of work per month. The loss of productivity was significantly higher for caregivers of patients with LN than caregivers of patients who were LNN. Conclusion Healthcare cost and loss of productivity were similar between patients with LN and patients who were LNN; the loss of productivity for caregivers is higher for patients with LN; and the healthcare cost is greater in ALN than in ILN. ER -