RT Journal Article
SR Electronic
T1 The Functional Polymorphism 844 A>G in FcαRI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.100427
DO 10.3899/jrheum.100427
A1 Jasper C.A. Broen
A1 Marieke J.H. Coenen
A1 Blanca Rueda
A1 Torsten Witte
A1 Leonid Padyukov
A1 Lars Klareskog
A1 Roger Hesselstrand
A1 Dirk M. Wuttge
A1 Carmen Simeon
A1 Norberto Ortego-Centeno
A1 Miguel González-Gay
A1 Anna Pros
A1 Nicholas Hunzelman
A1 Gabriela Riemekasten
A1 Alexander Kreuter
A1 Madelon Vonk
A1 Rafaella Scorza
A1 Lorenzo Beretta
A1 Paulo Airò
A1 Piet L.C.M. van Riel
A1 Robert Kimberly
A1 Javier Martin
A1 Jeffrey Edberg
A1 Timothy R.D.J. Radstake
YR 2010
UL http://www.jrheum.org/content/early/2010/12/12/jrheum.100427.abstract
AB Objective To investigate the role of the FcαRI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. Methods The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The FcαRI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. Results We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. Conclusion Our data show that the FcαRI 844 A>G polymorphism is not associated with SSc or RA susceptibility.