RT Journal Article SR Electronic T1 The Functional Polymorphism 844 A>G in FcαRI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.100427 DO 10.3899/jrheum.100427 A1 Jasper C.A. Broen A1 Marieke J.H. Coenen A1 Blanca Rueda A1 Torsten Witte A1 Leonid Padyukov A1 Lars Klareskog A1 Roger Hesselstrand A1 Dirk M. Wuttge A1 Carmen Simeon A1 Norberto Ortego-Centeno A1 Miguel González-Gay A1 Anna Pros A1 Nicholas Hunzelman A1 Gabriela Riemekasten A1 Alexander Kreuter A1 Madelon Vonk A1 Rafaella Scorza A1 Lorenzo Beretta A1 Paulo Airò A1 Piet L.C.M. van Riel A1 Robert Kimberly A1 Javier Martin A1 Jeffrey Edberg A1 Timothy R.D.J. Radstake YR 2010 UL http://www.jrheum.org/content/early/2010/12/12/jrheum.100427.abstract AB Objective To investigate the role of the FcαRI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. Methods The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The FcαRI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. Results We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. Conclusion Our data show that the FcαRI 844 A>G polymorphism is not associated with SSc or RA susceptibility.