TY - JOUR T1 - The Functional Polymorphism 844 A&gt;G in Fc<sub>α</sub>RI (<em>CD89</em>) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.100427 SP - jrheum.100427 AU - Jasper C.A. Broen AU - Marieke J.H. Coenen AU - Blanca Rueda AU - Torsten Witte AU - Leonid Padyukov AU - Lars Klareskog AU - Roger Hesselstrand AU - Dirk M. Wuttge AU - Carmen Simeon AU - Norberto Ortego-Centeno AU - Miguel González-Gay AU - Anna Pros AU - Nicholas Hunzelman AU - Gabriela Riemekasten AU - Alexander Kreuter AU - Madelon Vonk AU - Rafaella Scorza AU - Lorenzo Beretta AU - Paulo Airò AU - Piet L.C.M. van Riel AU - Robert Kimberly AU - Javier Martin AU - Jeffrey Edberg AU - Timothy R.D.J. Radstake Y1 - 2010/12/15 UR - http://www.jrheum.org/content/early/2010/12/12/jrheum.100427.abstract N2 - Objective To investigate the role of the FcαRI 844 A&gt;G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. Methods The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The FcαRI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. Results We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. Conclusion Our data show that the FcαRI 844 A&gt;G polymorphism is not associated with SSc or RA susceptibility. ER -