TY - JOUR T1 - Candidate Gene Association Study of Magnetic Resonance Imaging-based Hip Osteoarthritis (OA): Evidence for <em>COL9A2</em> Gene as a Common Predisposing Factor for Hip OA and Lumbar Disc Degeneration JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.100080 SP - jrheum.100080 AU - Annu Näkki AU - Tapio Videman AU - Urho M. Kujala AU - Matti Suhonen AU - Minna Männikkö AU - Leena Peltonen AU - Michele C. Battié AU - Jaakko Kaprio AU - Janna Saarela Y1 - 2010/12/15 UR - http://www.jrheum.org/content/early/2010/12/12/jrheum.100080.abstract N2 - Objective To study whether gene variants associated with lumbar disc degeneration (LDD) phenotypes are also associated with hip osteoarthritis (OA). Methods Magnetic resonance imaging (MRI)-based hip OA changes for 345 twins were assessed and 99 single-nucleotide polymorphisms (SNP) were analyzed. Results Variants in the COL9A2 (rs7533552, p = 0.0025) and COL10A1 (rs568725, p = 0.002) genes showed association with hip OA. Conclusion The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases. ER -