RT Journal Article SR Electronic T1 Botulinum Toxin Intramuscular Injections for Neck Pain: A Systematic Review and Metaanalysis JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.100739 DO 10.3899/jrheum.100739 A1 Pierre Langevin A1 Janet Lowcock A1 Jeffrey Weber A1 May Nolan A1 Anita R. Gross A1 Paul M. Peloso A1 John Roberts A1 Nadine Graham A1 Charles H. Goldsmith A1 Stephen J. Burnie A1 Ted Haines YR 2010 UL http://www.jrheum.org/content/early/2010/11/25/jrheum.100739.abstract AB Objective To assess the effect of intramuscular botulinum toxin type A (BoNT-A) injections on pain, function/disability, global perceived effect, and quality of life (QOL) in adults with neck pain (NP). Methods We searched Central, Medline, and Embase databases up to June 2010. A minimum of 2 authors independently selected articles, abstracted data, and assessed risk of bias and clinical applicability. We estimated standard mean differences (SMD) with 95% CI, relative risks (RR), and performed metaanalyses (SMDp) using a random-effects model for nonheterogeneous data. The approach of the Grading of Recommendations Assessment, Development, and Evaluation working group summarizes the quality of evidence. Results We selected 14 trials. High-quality evidence suggested BoNT-A was no better than saline at 4 weeks [4 trials/183 participants; SMDp –0.21 (95% CI –0.50 to 0.07)] and 6 months for chronic NP. Moderate-quality evidence showed a similar effect for subacute/chronic whiplash-associated disorder (WAD) on pain [4 trials/122 participants; SMDp –0.21 (95% CI –0.57 to 0.15)], disability, and QOL. Very low-quality evidence indicated BoNT-A combined with exercise and analgesics was not significant for chronic NP reduction at 4 weeks [3 trials/114 participants; SMDp –0.08 (95% CI –0.45 to 0.29)] but was at 6 months [2 trials/43 participants; SMDp –0.66 (95% CI –1.29 to –0.04)]. Conclusion Current evidence does not confirm a clinically or statistically significant benefit of BoNT-A used alone on chronic NP in the short term or on subacute/chronic WAD pain, disability, and QOL. Larger trials, subgroups, and predictors of responses defined a priori (to facilitate selection of patients most likely to benefit) and factorial designs to explore BoNT as an adjunct treatment to physiotherapeutic exercise and analgesics are needed.