RT Journal Article
SR Electronic
T1 Disease Phenotypes and Gender Association of FCRL3 Single-Nucleotide Polymorphism ‒169T/C in Taiwanese Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.100437
DO 10.3899/jrheum.100437
A1 Ji-Yih Chen
A1 Chin-Man Wang
A1 Yeong-Jian Jan Wu
A1 Shin-Ning Kuo
A1 Chiung-Fang Shiu
A1 Su-Wei Chang
A1 Yen-Tsun Lin
A1 Huei-Huang Ho
A1 Jianming Wu
YR 2010
UL http://www.jrheum.org/content/early/2010/11/12/jrheum.100437.abstract
AB Objective To investigate the association of the functional FCRL3 single-nucleotide polymorphism (SNP) –169T/C with disease phenotypes and susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in Taiwanese. Methods FCRL3 SNP –169T/C was genotyped in 573 patients with SLE, 670 patients with RA, and 758 controls. Genotype distributions and allele frequencies were compared among the 3 groups as aggregates or as stratified by clinical characteristics, autoantibody profile, and sex within patient groups. Results Overall, FCRL3 SNP –169T/C was not associated with susceptibility to either SLE or RA. However, –169CC genotype was significantly reduced in leukopenia-positive SLE patients as compared to the leukopenia-negative SLE patients (CC vs CT+TT, p = 6 × 10–4, OR 0.444, 95% CI 0.279–0.708) and controls (p = 6.1 × 10–3, OR 0.583, 95% CI 0.396–0.857). On the other hand, –169TT genotypes were significantly more numerous in RA patients with non-destructive disease as compared with patients with destructive disease (CC+CT vs TT: p = 0.007, OR 1.672, 95% CI 1.149–2.432). The –169T allele frequency was also significantly increased in non-destructive RA compared with patients with destructive disease (C vs T: p = 0.010, OR 1.423, 95% CI 1.089–1.859). FCRL3 SNP –169TT homozygous donors were significantly more numerous among female cyclic citrullinated peptide (CCP)-negative RA patients versus female CCP-positive RA patients (CC+CT vs TT: p = 0.019, OR 1.64, 95% CI 1.085–2.479). Conclusion The functional FCRL3 SNP –169T/C appears to play important roles in the development of certain phenotypes such as SLE leukopenia and RA disease severity in Taiwanese patients with SLE and RA.