RT Journal Article SR Electronic T1 Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.100652 DO 10.3899/jrheum.100652 A1 So-Young Bang A1 Tae-Hwan Kim A1 Bitnara Lee A1 Eunji Kwon A1 Sang Hyun Choi A1 Ki Soo Lee A1 Seung Cheol Shim A1 Angela Pope A1 Proton Rahman A1 John D. Reveille A1 Robert D. Inman YR 2010 UL http://www.jrheum.org/content/early/2010/10/28/jrheum.100652.abstract AB Objective Investigators from the Australo-Anglo-American Spondyloarthritis Consortium have reported additional genes associated with ankylosing spondylitis (AS) susceptibility including IL1R2, ANTXR2, and gene deserts at 2p15 and 21q22. We evaluated these new candidate genes in a large cohort of Korean patients with AS. Methods A group of 1164 patients with AS and 752 healthy controls were enrolled for our study. Eight single-nucleotide polymorphisms (SNP) were analyzed to define genetic association with AS by MassARRAY system. Results Significant positive associations of AS with endoplasmic reticulum aminopeptidase 1 SNP, rs27037 (p = 1.31 × 10–4), and rs27434 (p = 4.59 × 10–6), were observed. The rs10865331 of gene desert at 2p15 also showed a significant association with AS (p = 4.63 × 10–5). Conclusion This is the first confirmation in a nonwhite population that genetic polymorphisms of rs27037, rs27434, and rs10865331 are associated with AS, implicating common pathogenetic mechanisms in Korean and white patients with AS.