TY - JOUR T1 - Evaluation of a Shared Autoimmune Disease-associated Polymorphism of TRAF6 in Systemic Sclerosis and Giant Cell Arteritis JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.120038 SP - jrheum.120038 AU - F. David Carmona AU - Aurora Serrano AU - Luis Rodríguez-Rodríguez AU - José Luis Callejas AU - Carmen P. Simeón AU - Patricia Carreira AU - Santos Castañeda AU - Roser Solans AU - Ricardo Blanco AU - Miguel A. González-Gay AU - Javier Martín Y1 - 2012/05/15 UR - http://www.jrheum.org/content/early/2012/05/14/jrheum.120038.abstract N2 - Objective We evaluated whether a single-nucleotide polymorphism (SNP) of the TRAF6 gene previously associated with systemic lupus erythematosus and rheumatoid arthritis may be a common risk factor for systemic sclerosis (SSc) and giant cell arteritis (GCA). Methods A total of 1185 patients with SSc, 479 patients with biopsy-proven GCA, and 1442 unrelated healthy controls of white Spanish origin were genotyped for the rs540386 variant using a specifically designed TaqMan© allele discrimination assay. Results No significant associations of this SNP with global SSc or GCA were found. This was also the case when the potential associations of the TRAF6 polymorphism with the main clinical phenotypes of the 2 diseases (e.g., limited cutaneous and diffuse cutaneous SSc, or presence of polymyalgia rheuma - tica and visual ischemic manifestations in GCA) were assessed. Conclusion Our data do not support a role of the rs540386 TRAF6 variant as a key component of the genetic network underlying SSc and GCA. ER -