RT Journal Article SR Electronic T1 NPSR1 Gene Is Associated with Reduced Risk of Rheumatoid Arthritis JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.111205 DO 10.3899/jrheum.111205 A1 Gema Robledo A1 Miguel Angel González-Gay A1 Benjamín Fernández-Gutiérrez A1 José Ramón Lamas A1 Alejandro Balsa A1 Dora Pascual-Salcedo A1 Santos Castañeda A1 Ricardo Blanco A1 Isidoro González-Alvaro A1 Antonio García A1 Enrique Raya A1 Carmen Gómez-Vaquero A1 Mario Delgado A1 Javier Martín YR 2012 UL http://www.jrheum.org/content/early/2012/04/29/jrheum.111205.abstract AB Objective Neuropeptide S receptor 1 (NPSR1) is a G protein-coupled receptor involved in immune response and is associated with several inflammatory diseases. We investigated the possible contribution of several polymorphisms in the intronic region of NPSR1 to rheumatoid arthritis (RA). Methods Genotyping of 7 single-nucleotide polymorphisms (SNP) was performed in a total of 1232 patients with RA and 983 healthy controls of Spanish white origin by real-time polymerase chain reaction technology, using the TaqMan 5’-allele discrimination assay. Results One out of the 7 SNP analyzed (rs740347) was associated with RA [p after Bonferroni correction (pBNF) = 1.2 × 10-3, OR 0.73]. An association was also observed with rheumatoid factor-positive and shared epitope-positive RA (pBNF = 0.011, OR 0.73; pBNF = 0.037, OR 0.75, respectively). Conclusion Our results show that variations in the NPSR1 intronic region are associated with low risk in patients with RA, supporting other evidence that this locus represents a common genetic factor in inflammatory diseases.