TY - JOUR T1 - Changes in Regional Brain Morphology in Neuropsychiatric Systemic Lupus Erythematosus JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.110833 SP - jrheum.110833 AU - Patricia C. Cagnoli AU - Pia C. Sundgren AU - Anson Kairys AU - Courtney C. Graft AU - Daniel J. Clauw AU - Stephen Gebarski AU - W. Joseph McCune AU - Tobias Schmidt-Wilcke Y1 - 2012/04/01 UR - http://www.jrheum.org/content/early/2012/03/25/jrheum.110833.abstract N2 - Objective Neuropsychiatric lupus (NPSLE) is a severe and potentially life-threatening condition, reported to occur in 25%–70% of patients with systemic lupus erythematosus (SLE). Brain imaging, especially magnetic resonance imaging, is frequently used to diagnose or exclude overt cerebral pathologies such as edema, hemorrhage, and central thrombosis. More advanced imaging techniques have been applied to demonstrate subtle changes in regional cerebral blood flow and brain structure. We investigated changes in regional gray-matter (GM) volume in SLE patients without neurological manifestations and NPSLE patients at an acute stage of the disease. Methods Using high-resolution structural images and voxel-based morphometry (VBM), we investigated regional GM volume in 20 NPSLE patients (within 2 weeks of the acute manifestation), 18 SLE patients without neurologic and/or psychiatric manifestations, and 18 healthy controls. Results VBM analyses revealed several regions of GM atrophy in various parts of the brain in NPSLE and SLE patients. GM atrophy was seen in both groups in the temporal and parietal lobes and was most pronounced in the posterior thalamus bilaterally. Both groups showed an increase in regional GM volume in the posterior parahippocampal gyrus. Conclusion Our data suggest that changes in regional brain morphology are present in acute NPSLE, but also in SLE (as compared to controls), which might be indicative of a subclinical neurodegenerative process. Further research is needed to investigate whether specific neuropsychiatric symptoms are related to these changes. ER -