TY - JOUR T1 - Effects of Smoking on Disease Activity and Radiographic Progression in Early Rheumatoid Arthritis JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.110410 SP - jrheum.110410 AU - Virginia Ruiz-Esquide AU - José A. Gómez-Puerta AU - Juan D. Cañete AU - Eduard Graell AU - Ivonne Vazquez AU - M. Guadalupe Ercilla AU - Odette Viñas AU - Antonio Gómez-Centeno AU - Isabel Haro AU - Raimon Sanmartí Y1 - 2011/11/01 UR - http://www.jrheum.org/content/early/2011/10/28/jrheum.110410.abstract N2 - Objective To analyze the effects of cigarette smoking on disease activity and radiographic damage in patients with early rheumatoid arthritis (RA). Methods Study subjects were 156 patients with early RA (< 2 yrs). Disease activity, therapeutic response, and radiographic progression were compared in smokers and nonsmokers at 24 months. Results At baseline, ever-smokers had earlier disease onset and a closer association with the shared epitope (SE), but not more seropositive disease. No significant differences were observed in disease activity and European League Against Rheumatism therapeutic responses between smokers and nonsmokers. Multivariate analysis showed that baseline Larsen score, the HLA-DRB*04 genotype, being female, and current smoking were associated with radiographic progression. Conclusion In patients with early RA, smoking was associated with earlier disease onset and the SE. Smoking was an independent factor of radiographic progression. ER -