RT Journal Article
SR Electronic
T1 Association Analysis of Polymorphisms in Lumican Gene and Systemic Lupus Erythematosus in a Taiwan Chinese Han Population
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.101310
DO 10.3899/jrheum.101310
A1 Pei-Chun Chang
A1 Yi Chen
A1 Ming-Tsong Lai
A1 Heng-Yuan Chang
A1 Chung-Ming Huang
A1 Hsin-Ping Liu
A1 Wei-Yong Lin
A1 Chih-Ho Lai
A1 Jim Jinn-Chyuan Sheu
A1 Fuu-Jen Tsai
YR 2011
UL http://www.jrheum.org/content/early/2011/08/30/jrheum.101310.abstract
AB Objective Lumican (LUM) is predominantly localized in areas of pathological fibrosis. To determine whether polymorphisms in LUM gene are associated with development of systemic lupus erythematosus (SLE), we analyzed 2 single-nucleotide polymorphisms (SNP) of LUM in a Taiwan Chinese Han population. Methods Participants included 168 patients with SLE and 192 age-matched controls in whom examinations had excluded SLE. Genotyping of –628 A/– (rs17018757) and c.1567 T/C polymorphisms in LUM were carried out in each patient and control using the polymerase chain reaction-restriction fragment-length polymorphism method, and validated by Taqman SNP genotyping assay. Data were correlated with the development of SLE and various clinical symptoms by chi-square analysis. Results Frequencies of C/C genotype and the C allele at c.1567 T/C were significantly higher in patients than controls. Polymorphism at c.1567 C/T was found to be associated with arthritis and photosensitivity in patients with SLE, which are both connective tissue-related symptoms. Conclusion The c.1567 T/C polymorphism of LUM is related to the development and clinical symptoms of SLE.