RT Journal Article
SR Electronic
T1 Preferential Association of Interferon Regulatory Factor 5 Gene Variants with Seronegative Rheumatoid Arthritis in 2 Swedish Case-Control Studies
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.110322
DO 10.3899/jrheum.110322
A1 Chuan Wang
A1 Heidi Kokkonen
A1 Johanna K. Sandling
A1 Martin Johansson
A1 Maria Seddighzadeh
A1 Leonid Padyukov
A1 Solbritt Rantapää-Dahlqvist
A1 Ann-Christine Syvänen
YR 2011
UL http://www.jrheum.org/content/early/2011/07/24/jrheum.110322.abstract
AB Objective Two interferon regulatory factor 5 (IRF5) gene variants were examined for association with rheumatoid arthritis (RA). Methods A total of 2300 patients with RA and 1836 controls were recruited from 2 independent RA studies in Sweden. One insertion-deletion polymorphism (CGGGG indel) and one single-nucleotide polymorphism (rs10488631) in the IRF5 gene were genotyped and analyzed within RA subgroups stratified by rheumatoid factor (RF) and anticitrullinated peptide antibodies (ACPA). Results The CGGGG indel was preferentially associated with the RF-negative (OR 1.29, p = 7.9 × 10–5) and ACPA-negative (OR 1.27, p = 7.3 × 10–5) RA subgroups compared to the seropositive counterparts. rs10488631 was exclusively associated within the seronegative RA subgroups (RF-negative: OR 1.24, p = 0.016; ACPA-negative: OR 1.27, p = 4.1 × 10–3). Conclusion Both the CGGGG indel and rs10488631 are relevant for RA susceptibility, especially for seronegative RA.