PT  - JOURNAL ARTICLE
AU  - Fleur Aubart
AU  - Bruno Crestani
AU  - Pascale Nicaise-Roland
AU  - Florence Tubach
AU  - Caroline Bollet
AU  - Karen Dawidowicz
AU  - Emilie Quintin
AU  - Gilles Hayem
AU  - Elisabeth Palazzo
AU  - Olivier Meyer
AU  - Sylvie Chollet-Martin
AU  - Philippe Dieudé
TI  - High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis
AID  - 10.3899/jrheum.101261
DP  - 2011 Mar 01
TA  - The Journal of Rheumatology
PG  - jrheum.101261
4099  - http://www.jrheum.org/content/early/2011/02/24/jrheum.101261.short
4100  - http://www.jrheum.org/content/early/2011/02/24/jrheum.101261.full
AB  - Objective To investigate whether levels of anti-cyclic citrullinated peptide antibodies (anti-CCP2) in patients with rheumatoid arthritis (RA) are associated with the co-occurrence of lung diseases. Methods A total of 252 RA patients were included in a cross-sectional study. Pulmonary disease was confirmed by high-resolution chest computed tomography scan. Circulating anti-CCP2 were quantified using ELISA. Multivariate logistic regression was conducted to identify independent risk factors for lung disease. Results Male sex (OR 3.29, 95% CI 1.59–6.80) and high anti-CCP2 levels (OR 1.49, 95% CI 1.25–1.78) were identified as independent risk factors for lung disease in the RA population. Conclusion High anti-CCP2 levels are associated with lung disease in the RA population.