RT Journal Article
SR Electronic
T1 Temporal Association of <em>Streptococcus</em>, <em>Staphylococcus</em>, and Parainfluenza Pediatric Hospitalizations and Hospitalized Cases of Henoch-Schönlein Purpura
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.100364
DO 10.3899/jrheum.100364
A1 Pamela F. Weiss
A1 Andrew J. Klink
A1 Xianqun Luan
A1 Chris Feudtner
YR 2010
UL http://www.jrheum.org/content/early/2010/09/09/jrheum.100364.abstract
AB Objective To determine if hospitalizations for specific infectious exposures are associated with hospital admissions for Henoch-Schönlein purpura (HSP). Methods We conducted a retrospective cohort study using administrative data of children admitted to 40 children’s hospitals between January 1, 2002, and December 31, 2008. We examined the association of standardized rates of group Aß-hemolytic Streptococcus (GABS), Staphylococcus aureus, parainfluenza, influenza, adenovirus, and respiratory syncytial virus (RSV)-associated hospital admissions with standardized rates of HSP hospital admissions on a month by month basis using autoregressive moving average process models to account for temporal autocorrelation and clustering by hospital. Results Among the 3,132 admissions for HSP observed over the 7-year study period, hospital admissions were most frequent September through April, but with substantial variability between hospitals for each month. Accounting for these month by month differences within each hospital, the rate of HSP admissions in a given month increased significantly as the standardized rates of GABS (p = 0.01), S. aureus (p &lt; 0.01), and parainfluenza (p = 0.03) admissions increased. Conclusion Our results demonstrate a local month by month temporal association between hospitalization for GABS, S. aureus, and parainfluenza and hospitalization for HSP. Future investigations will be required to determine causality.