RT Journal Article
SR Electronic
T1 Influence of CD40 rs1883832 Polymorphism in Susceptibility to and Clinical Manifestations of Biopsy-proven Giant Cell Arteritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.100362
DO 10.3899/jrheum.100362
A1 Luis Rodríguez-Rodríguez
A1 Santos Castañeda
A1 Tomás R. Vázquez-Rodríguez
A1 Inmaculada C. Morado
A1 Beatriz Marí-Alfonso,
A1 Carmen Gómez-Vaquero
A1 José A. Miranda-Filloy
A1 Javier Narvaez
A1 Norberto Ortego-Centeno
A1 Ricardo Blanco
A1 Benjamín Fernández-Gutiérrez
A1 Javier Martín
A1 Miguel A. González-Gay
YR 2010
UL http://www.jrheum.org/content/early/2010/08/10/jrheum.100362.abstract
AB Objective To assess the potential association between CD40 rs1883832 polymorphism and biopsyproven giant cell arteritis (GCA). We also studied the influence of the polymorphism on phenotypic expression of this vasculitis, in particular the development of visual ischemic manifestations. Methods Three hundred five Spanish patients with biopsy-proven GCA and 788 matched controls were assessed. DNA from patients and controls was obtained from peripheral blood. Samples were genotyped for the CD40 rs1883832 C/T polymorphism using a predesigned TaqMan allele discrimination assay and by polymerase chain reaction amplification. Results Patients with GCA showed a trend toward a higher frequency of the minor allele homozygote of rs1883832 (TT) compared to healthy controls (12.1% vs 8.3%, respectively; p = 0.05, OR 1.54, 95% CI 0.98–2.40). Also, a marginally significant increased frequency of the minor allele T was observed in patients with GCA who had visual ischemic manifestations (36.9%) compared to those without visual ischemic manifestations (27.7%; p = 0.04, OR 1.53, 95% CI 0.99–2.34). In this regard, patients with GCA carrying the minor allele T (either TT or TC) experienced visual ischemic manifestations more commonly than those carrying the CC genotype (58.5% vs 44.2%; p = 0.04, OR 1.78, 95% CI 0.99–3.22). Conclusion Our results suggest a potential implication of the CD40 rs1883832 C/T polymorphism in susceptibility to visual ischemic manifestations in individuals with biopsy-proven GCA.