TY - JOUR T1 - LupusQoL-US Benchmarks for US Patients with Systemic Lupus Erythematosus JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.091443 SP - jrheum.091443 AU - Meenakshi Jolly AU - Simon A. Pickard AU - Rachel A. Mikolaitis AU - Roger A. Rodby AU - Winston Sequeira AU - Joel A. Block Y1 - 2010/08/17 UR - http://www.jrheum.org/content/early/2010/08/10/jrheum.091443.abstract N2 - Objective The LupusQoL-US instrument was recently validated in the US. We studied the benchmarks for a US patient cohort with systemic lupus erythematosus (SLE) and relevant demographic and disease correlates. Methods LupusQoL-US was administered to 185 patients with SLE. Demographic data (age, sex, ethnicity, marital status) and disease features (duration, disease activity and damage) were assessed simultaneously. Descriptive statistics were obtained. LupusQoL-US domain scores were calculated, and compared by sex, ethnicity, and marital status using nonparametric tests. Correlation between LupusQoL-US domains and age, disease duration, disease activity, and disease damage were obtained. Results Mean age of patients was 42.2 ± 14.5 years; 94% of subjects were women. African American patients comprised 60% of the study cohort. The most affected domains were Fatigue and Physical Health. The least affected was Intimate Relationships. Age correlated with Physical Health, Pain, and Body Image (r = 0.15–0.18). Differences were observed based on sex and marital status, but not by ethnicity; there the LupusQoL-US correlated inversely with disease activity (r = –0.001 to –0.36) and damage (r = –0.003 to –0.40). Conclusion All domains of the LupusQoL-US based health related quality of life (HRQOL) were affected adversely. HRQOL varied by age, sex, and marital status in our SLE cohort. ER -