@article {Richettejrheum.100234, author = {Pascal Richette and S{\'e}bastien Ottaviani and Eric Vicaut and Thomas Bardin}, title = {Musculoskeletal Complications of Hereditary Hemochromatosis: A Case-Control Study}, elocation-id = {jrheum.100234}, year = {2010}, doi = {10.3899/jrheum.100234}, publisher = {The Journal of Rheumatology}, abstract = {Objective Arthropathy that mimics osteoarthritis (OA) and osteoporosis (OP) is considered a classic complication of hereditary hemochromatosis (HH) but has never been investigated in a cross-sectional study.We investigated whether HH is associated with increased prevalence of OA and OP and related factors. Methods A self-administered questionnaire was completed by 306 patients with HH and 304 age and sex-matched unaffected controls. Results The mean age of patients was 60.1 {\textpm} 11.3 years, and 47.4\% were women. More patients with HH than controls had been given a diagnosis of OA: 50.5\% vs 28.9\% [adjusted OR (aOR) 2.5, 95\% CI 1.8{\textendash}3.6]. Compared with controls, patients with HH had a higher risk of knee (aOR 5.3, 95\% CI 1.1{\textendash}25.6) and hip replacement prosthesis (aOR 5.2, 95\% CI 2.2-11.9). More patients than controls had been diagnosed with OP: 23.3\% vs 4.6\% (aOR 7.3, 95\% CI 3.2{\textendash}17.0). Patients with HH showed an increased prevalence, although not significant, of wrist (aOR 1.7, 95\% CI 0.9-3.0) or vertebral fractures (aOR 1.7, 95\% CI 0.8-3.8). The severity of iron overload, as defined by a ferritin level \> 1000 {\textmu}g/l at diagnosis, was associated with OA (p = 0.0005), OP (p = 0.01), presence of hip prosthesis (p = 0.04), wrist fractures (p = 0.002), and vertebral fractures (p = 0.02). Conclusion This case-control study strongly suggests a significant association among HH, OA, and OP. Joint involvement can be severe, especially in patients with substantially elevated ferritin levels.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2010/07/29/jrheum.100234}, eprint = {https://www.jrheum.org/content/early/2010/07/29/jrheum.100234.full.pdf}, journal = {The Journal of Rheumatology} }