TY - JOUR T1 - Cerebral Blood Flow in Depressed Patients with Systemic Lupus Erythematosus JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.100121 SP - jrheum.100121 AU - Giampiero Giovacchini AU - Marta Mosca AU - Gianpiero Manca AU - Mauro Della Porta AU - Claudia Neri AU - Stefano Bombardieri AU - Andrea Ciarmiello AU - H. William Strauss AU - Giuliano Mariani AU - Duccio Volterrani Y1 - 2010/07/01 UR - http://www.jrheum.org/content/early/2010/06/28/jrheum.100121.abstract N2 - Objective To characterize the neural circuitry involved in depression associated with systemic lupus erythematosus (SLE), we used single photon emission computed tomography (SPECT) to study regional cerebral blood flow (CBF) in patients with SLE. Methods SPECT with 99mTc-ethylcysteinate dimer was performed in 30 depressed women patients with SLE, in 14 women patients with SLE and without history of neuropsychiatric disorders, and in 25 healthy women controls. Magnetic resonance imaging was done for all subjects for diagnostic purposes. Analysis of CBF patterns was performed using statistical parametric mapping. Statistical significance was taken at uncorrected p < 0.001 at cluster level. Results There were no significant differences between depressed and nondepressed patients with SLE for any rheumatologic variable. In comparison to healthy controls, depressed patients with SLE had significantly reduced CBF in bilateral frontal and temporal cortex; global maximum was located in the left precentral gyrus. There were no significant CBF differences between nondepressed patients with SLE and controls. Compared to nondepressed patients with SLE, depressed patients with SLE had significantly lower CBF in 2 clusters that had their local maxima in the right precentral gyrus and in the left superior temporal gyrus. The duration of SLE correlated with decreased perfusion in the left middle and superior frontal gyrus. Conclusion Depressed patients with SLE have CBF reductions in discrete temporal and frontal regions that may account for depressive symptoms. ER -