PT  - JOURNAL ARTICLE
AU  - José Ramón Lamas
AU  - Luis Rodríguez-Rodríguez
AU  - Jezabel Varadé
AU  - Pedro López-Romero
AU  - Pilar Tornero-Esteban
AU  - Lydia Abasolo
AU  - Elena Urcelay
AU  - Benjamín Fernández-Gutiérrez
TI  - Influence of <em>IL6R</em> rs8192284 Polymorphism Status in Disease Activity in Rheumatoid Arthritis
AID  - 10.3899/jrheum.091455
DP  - 2010 Jun 15
TA  - The Journal of Rheumatology
PG  - jrheum.091455
4099  - http://www.jrheum.org/content/early/2010/06/13/jrheum.091455.short
4100  - http://www.jrheum.org/content/early/2010/06/13/jrheum.091455.full
AB  - Objective To analyze the influence of IL6R rs8192284 polymorphism on the disease activity of rheumatoid arthritis (RA). Methods Patients with RA (n = 281) were followed for a median of 4.2 years. A total of 1143 disease activity measurements using the 28-joint count Disease Activity Score (DAS28) were performed. A mixed-effect model was used to analyze the measurements. Results A statistically significant interaction was observed between IL6R rs8192284 polymorphism and the presence of anticyclic citrullinated peptide (anti-CCP) antibodies (p = 0.008). An inverse relationship between the polymorphism and DAS28 was observed depending on anti-CCP status. Conclusion The anti-CCP status in patients with RA determines the association between the IL6R rs8192284 polymorphism and disease activity.