RT Journal Article
SR Electronic
T1 Functional Variants of Fc Gamma Receptor (FCGR2A) and FCGR3A Are Not Associated with Susceptibility to Systemic Sclerosis in a Large European Study (EUSTAR)
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.091259
DO 10.3899/jrheum.091259
A1 Behrooz Z. Alizadeh
A1 Jasper Broen
A1 Blanca Rueda
A1 Roger Hesselstrand
A1 Dirk Wuttge
A1 Carmen Simeon
A1 Norberto Ortego-Centeno
A1 Miguel Gonzalez-Gay
A1 Anna Pros
A1 Ariane Herrick
A1 Jane Worthington
A1 Christopher Denton
A1 Carmen Fonseca
A1 Gabriela Riemekasten
A1 Madelon C. Vonk
A1 Frank van den Hoogen
A1 Serena Guiducci
A1 Marco Matucci-Cerinic
A1 Rafaella Scorza
A1 Lorenzo Beretta
A1 Paolo Airó
A1 Marieke Coenen
A1 Javier Martin
A1 Bobby P.C. Koeleman
A1 Timothy R.D.J. Radstake
YR 2010
UL http://www.jrheum.org/content/early/2010/06/13/jrheum.091259.abstract
AB Objective To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. Methods A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>C functional variants in 6 independent European cohorts of white patients with SSc, and white controls. The cohorts comprised 165 Dutch patients with SSc and 1326 controls, 236 Spanish patients with SSc and 257 controls, 267 German patients with SSc and 270 controls, 202 Swedish patients with SSc and 261 controls, 416 Italian patients with SSc and 157 controls, and additionally 280 English patients with SSc. Genotyping was performed using Taqman 5′ allelic discrimination assay. The study reached a 99% power to detect the effect of a polymorphism at an OR of 1.3. Results Neither FCGR2A 519A>G nor FCGR3A 559A>C was significantly associated with susceptibility to SSc. We did not find an association with specific disease phenotypes, limited or diffuse cutaneous involvement, autoantibody profiles, or pulmonary involvement. Conclusion Our study strongly suggests the lack of a role for the FCGR2A 519A>G and FCGR3A 559A>C polymorphisms in SSc susceptibility or clinical phenotype in 6 independent European cohorts.