PT  - JOURNAL ARTICLE
AU  - Duvuru Geetha
AU  - Mark Haas
AU  - Edward S. Kraus
AU  - Hamid Rabb
AU  - Philip Seo
TI  - Renal Transplant in Wegener's Granulomatosis Compared to Microscopic Polyangiitis
AID  - 10.3899/jrheum.091202
DP  - 2010 Jun 01
TA  - The Journal of Rheumatology
PG  - jrheum.091202
4099  - http://www.jrheum.org/content/early/2010/05/27/jrheum.091202.short
4100  - http://www.jrheum.org/content/early/2010/05/27/jrheum.091202.full
AB  - Objective Antineutrophil cytoplasmic antibody-associated vasculitis is an important cause of endstage renal disease. Our aim was to investigate how the underlying vasculitis diagnosis may influence outcomes following renal transplant. Methods We undertook a retrospective cohort study of patients who underwent renal transplant at the Johns Hopkins Hospital between 1999 and 2008. Results Detailed followup data were available for 11 patients with Wegener’s granulomatosis (WG) and 6 with microscopic polyangiitis (MPA), representing 799 patient-months of observation. Patients with WG remained on hemodialysis longer (and may have had slightly worse renal outcomes following transplant) than patients with MPA. Four patients with WG experienced adverse events following renal transplant: 2 experienced rejection and 2 vasculitis flare. Among the patients with MPA, there was 1 episode of rejection and no vasculitis flare. Conclusion Whether outcomes following renal transplant may be influenced by the underlying diagnosis of vasculitis merits further study.