TY - JOUR T1 - More Night Than Day - Circadian Rhythms in Polymyalgia Rheumatica and Ankylosing Spondylitis - REVIEW JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.091283 SP - jrheum.091283 AU - Cornelia M. Spies AU - Maurizio Cutolo AU - Rainer H. Straub AU - Gerd-RĂ¼diger Burmester AU - Frank Buttgereit Y1 - 2010/04/01 UR - http://www.jrheum.org/content/early/2010/03/28/jrheum.091283.abstract N2 - The circadian rhythm of symptoms in patients with chronic inflammatory diseases is well known. Circadian rhythms could be used to identify targets for time-adapted antiinflammatory therapies, which are administered prior to the flare of cytokine synthesis and inflammatory activity. In recent years, the diurnal variations in rheumatoid arthritis have been described precisely for pain, stiffness, and functional disability, as well as the underlying cyclic variations in hormone levels and cytokine concentrations. This review summarizes the current knowledge on circadian rhythms in other rheumatic diseases, focusing on polymyalgia rheumatica and ankylosing spondylitis. ER -