RT Journal Article
SR Electronic
T1 Influence of STAT4 Polymorphism in Primary Sjögren's Syndrome
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.091007
DO 10.3899/jrheum.091007
A1 Rogelio J. Palomino-Morales
A1 Lina-Marcela Diaz-Gallo
A1 Torsten Witte
A1 Juan-Manuel Anaya
A1 Javier Martin
YR 2010
UL http://www.jrheum.org/content/early/2010/03/28/jrheum.091007.abstract
AB Objective To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren’s syndrome (SS). Methods Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date. Results Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82–1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96–2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 × 10–6, OR 1.40, 95% CI 1.21–1.62). Conclusion These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene.