RT Journal Article
SR Electronic
T1 Association of the <em>MCP-1</em> -2518 A/G Polymorphism and No Association of Its Receptor <em>CCR2</em> -64 V/I Polymorphism with Lupus Nephritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.090681
DO 10.3899/jrheum.090681
A1 Patricia Malafronte
A1 Jose Mauro Vieira, Jr
A1 Alexandre Carlos Pereira
A1 Jose Eduardo Krieger
A1 Rui Toledo Barros
A1 Viktoria Woronik
YR 2010
UL http://www.jrheum.org/content/early/2010/03/12/jrheum.090681.abstract
AB Objective To evaluate whether the A/G polymorphism at position –2518 in the regulatory region of the monocyte chemoattractant protein-1 (MCP-1) or the V/I polymorphism at position –64 of the receptor, CCR2, are associated with lupus nephritis (LN) or any clinical characteristics of the disease or with renal survival in a patient population. Methods We selected 197 patients with lupus nephritis and 220 matched healthy controls for study. MCP-1 and CCR2 genotyping was performed by polymerase chain reaction. Clinical and laboratory data were compiled from patients’ charts over followup that ranged from 6 months to 10 years. Results The G/G genotype of MCP-1 was more common in LN patients (p = 0.019), while the A allele was associated with healthy controls (p = 0.007) as was the V allele of CCR2 (p = 0.046) compared to LN patients. Clinical index measures [SLE Disease Activity Index (SLEDAI)], immunological markers, renal histology, renal function at enrollment, and renal survival were not influenced by these polymorphisms. A less aggressive renal disease, measured by renal SLEDAI index, was associated with the V allele of the CCR2 gene polymorphism. Conclusion These findings support that MCP-1 –2518 G/G is associated with LN but there was no association of this genotype with renal function or renal survival. When studying CCR2 –64 V/I polymorphism we showed a positive association of the V allele with healthy controls but no association of the genotype with LN patients.