@article {Ottenjrheum.090550, author = {Marieke H. Otten and Femke H.M. Prince and Marinka Twilt and Marion A.J. van Rossum and Wineke Armbrust and Esther P.A.H. Hoppenreijs and Sylvia Kamphuis and Yvonne Koopman-Keemink and Nico M. Wulffraat and Simone L. Gorter and Rebecca ten Cate and Lisette W.A. van Suijlekom-Smit}, title = {Delayed Clinical Response in Patients with Juvenile Idiopathic Arthritis Treated with Etanercept}, elocation-id = {jrheum.090550}, year = {2010}, doi = {10.3899/jrheum.090550}, publisher = {The Journal of Rheumatology}, abstract = {Objective To evaluate response in patients with juvenile idiopathic arthritis (JIA) who failed to meet response criteria after 3 months of etanercept treatment. Methods This was a prospective ongoing multicenter observational study of all Dutch patients with JIA using etanercept. Response according to American College of Rheumatology Pediatric 30 criteria was assessed at study start and at 3 and 15 months. Results In total we studied 179 patients of median age 5.8 years at disease onset; 70\% were female. Thirty-four patients did not respond after 3 months, of which 20 continued etanercept and 11 achieved response thereafter. Conclusion The delayed clinically relevant response in a substantial proportion of patients who initially did not respond justifies the consideration of continuing therapy to at least 6 months.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2010/01/11/jrheum.090550}, eprint = {https://www.jrheum.org/content/early/2010/01/11/jrheum.090550.full.pdf}, journal = {The Journal of Rheumatology} }