RT Journal Article
SR Electronic
T1 Pancreatitis in Systemic Lupus Erythematosus: Frequency and Associated Factors - A Review of the Hopkins Lupus Cohort
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.090829
DO 10.3899/jrheum.090829
A1 Ashima Makol
A1 Michelle Petri
YR 2009
UL http://www.jrheum.org/content/early/2009/12/21/jrheum.090829.abstract
AB Objective Pancreatitis is a rare but potentially life-threatening complication of systemic lupus erythematosus (SLE). Vasculitis of the gastrointestinal tract is the most commonly proposed mechanism. We determined the frequency of SLE-related pancreatitis in the Hopkins Lupus Cohort. Methods A large prospective cohort of 1811 patients with SLE was reviewed and clinical and laboratory measures of SLE patients who developed pancreatitis were compared to patients who did not develop pancreatitis. Results Four percent of patients with SLE had pancreatitis due to SLE. The best multivariate model of clinical and laboratory associations included hypertriglyceridemia, psychosis, pleurisy, gastritis, and anemia. Conclusion Hypertriglyceridemia appears to be a strong associate of pancreatitis in SLE, but antiphospholipid antibodies are not. SLE patients with psychosis and pleurisy are at increased risk for pancreatitis.