TY - JOUR T1 - Metabolic Syndrome and the Incidence of Symptomatic Deep Vein Thrombosis Following Total Knee Arthroplasty JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.090282 SP - jrheum.090282 AU - Rajiv Gandhi AU - Fahad Razak AU - Peggy Tso AU - J. Roderick Davey AU - Nizar N. Mahomed Y1 - 2009/08/14 UR - http://www.jrheum.org/content/early/2009/08/13/jrheum.090282.abstract N2 - Objective We asked if patients with metabolic syndrome undergoing total knee replacement (TKR) have an increased risk for symptomatic deep vein thrombosis (DVT) at 3 months followup. Methods We reviewed 1460 patients from our joint registry undergoing primary, unilateral TKR between 1998-2006. Demographic variables of age, sex, comorbidity, and education were retrieved. Metabolic syndrome was defined as body mass index above 30 kg/m2, diabetes, hypertension, and hypercholesterolemia. Logistic regression was used to examine the relationship of metabolic syndrome on the incidence of DVT. Results The overall incidence of symptomatic DVT was 4.4% (65/1460). Patients with metabolic syndrome had an increased incidence of DVT compared to those without metabolic syndrome (15.5% vs 3.4%).Adjusted analysis showed that the risk of symptomatic DVT in patients with metabolic syndrome was 3.2 times [odds ratio 3.2, 95% CI (1.0,15.4), p = 0.04] the risk in those without metabolic syndrome. Conclusion Hospital protocols developed for prophylactic anticoagulation following TKR should give special consideration to patients with metabolic syndrome. ER -