TY - JOUR T1 - Observations on Cryoglobulin Testing: II. The Association of Oligoclonal Mixed Cryoglobulinemia with Cirrhosis in Patients Infected with Hepatitis C Virus JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.090189 AU - Francesco G. De Rosa AU - György Ábel AU - Vincent Agnello Y1 - 2009/06/16 UR - http://www.jrheum.org/content/early/2009/06/15/jrheum.090189.abstract N2 - Objective To determine whether a mixed cryoglobulin type correlated with cirrhosis in patients infected with hepatitis C virus (HCV). Methods We investigated the results of mixed cryoglobulin tests performed in the clinical laboratory on patients with and without HCV infection. Results A higher prevalence of oligoclonal cryoglobulins designated Type IIa was present in HCV-infected patients with cirrhosis than in those without cirrhosis. Conclusion An association of Type IIa cryoglobulins with cirrhosis in HCV-infected patients has not previously been reported. ER -