RT Journal Article
SR Electronic
T1 Mannose-Binding Lectin Gene Polymorphisms Are Associated with Disease Activity and Physical Disability in Untreated, Anti-Cyclic Citrullinated Peptide-Positive Patients with Early Rheumatoid Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.080846
DO 10.3899/jrheum.080846
A1 Søren Jacobsen
A1 Peter  Garred
A1 Hans Ole Madsen
A1 Niels H.H. Heegaard
A1 Merete Lund Hetland
A1 Kristian Stengaard-Pedersen
A1 Peter Junker
A1 Tine Lottenburger
A1 Torkel Ellingsen
A1 Lis Smedegaard Andersen
A1 Ib Hansen
A1 Henrik Skjødt
A1 Jens Kristian  Pedersen
A1 Ulrik Birk Lauridsen
A1 Anders J. Svendsen
A1 Ulrik Tarp
A1 Jan Pødenphant
A1 Hanne Lindegaard
A1 Aage Vestergaard
A1 Mikkel Østergaard
A1 Kim Hørslev-Petersen
YR 2009
UL http://www.jrheum.org/content/early/2009/02/25/jrheum.080846.abstract
AB Objective To study the association between polymorphisms in the mannose-binding lectin gene (MBL2) and disease activity, physical disability, and joint erosions in patients with newly diagnosed rheumatoid arthritis (RA). Methods Patients with early RA (n = 158) not previously treated with disease modifying antirheumatic drugs, participating in a treatment trial (CIMESTRA study) were examined at inclusion for MBL2 pooled structural genotypes (O/O, A/O, A/A), regulatory MBL2 promoter polymorphism in position –221 (XX, XY,YY), anti-cyclic citrullinated peptide 2 antibodies (anti-CCP2), disease activity by Disease Activity Score-28 (DAS28 score), physical disability by Health Assessment Questionnaire (HAQ) score, and erosive changes in hands and feet (Sharp-van der Heijde score). Results Eight patients were homozygous MBL2 defective (O/O), 101 belonged to an intermediate group, and 49 were MBL2 high producers (YA/YA). Anti-CCP was present in 93 patients (59%). High scores of disease activity, C-reactive protein-based DAS28 (p = 0.02), and physical disability by HAQ (p = 0.01) were associated with high MBL2 expression genotypes in a gene-dose dependent way, but only in anti-CCP-positive patients. At this early stage of the disease there was no association with erosion score from radiographs. Conclusion The results point to a synovitis-enhancing effect of MBL in anti-CCP-positive RA, whereas such an effect was not demonstrated for joint erosions.