RT Journal Article
SR Electronic
T1 Bone Area Provides a Responsive Outcome Measure for Bone Changes in Short-term Knee Osteoarthritis Studies
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2179
OP 2182
DO 10.3899/jrheum.151118
VO 43
IS 12
A1 Michael A. Bowes
A1 Rose A. Maciewicz
A1 John C. Waterton
A1 David J. Hunter
A1 Philip G. Conaghan
YR 2016
UL http://www.jrheum.org/content/43/12/2179.abstract
AB Objective. To analyze the 3-D bone area from an osteoarthritis (OA) cohort demonstrating no change in cartilage thickness.Methods. Twenty-seven women with painful medial knee OA had magnetic resonance images at 0, 3, and 6 months. Images were analyzed using active appearance models.Results. At 3 and 6 months, the mean change in medial femoral bone area was 0.34% (95% CI 0.04–0.64) and 0.61% (95% CI 0.32–0.90), respectively. Forty-one percent of the subjects had progression greater than the smallest detectable difference at 6 months.Conclusion. In this small cohort at high risk of OA progression, bone area changed at 3 and 6 months when cartilage morphometric measures did not.