PT - JOURNAL ARTICLE AU - Michael A. Bowes AU - Rose A. Maciewicz AU - John C. Waterton AU - David J. Hunter AU - Philip G. Conaghan TI - Bone Area Provides a Responsive Outcome Measure for Bone Changes in Short-term Knee Osteoarthritis Studies AID - 10.3899/jrheum.151118 DP - 2016 Dec 01 TA - The Journal of Rheumatology PG - 2179--2182 VI - 43 IP - 12 4099 - http://www.jrheum.org/content/43/12/2179.short 4100 - http://www.jrheum.org/content/43/12/2179.full SO - J Rheumatol2016 Dec 01; 43 AB - Objective. To analyze the 3-D bone area from an osteoarthritis (OA) cohort demonstrating no change in cartilage thickness.Methods. Twenty-seven women with painful medial knee OA had magnetic resonance images at 0, 3, and 6 months. Images were analyzed using active appearance models.Results. At 3 and 6 months, the mean change in medial femoral bone area was 0.34% (95% CI 0.04–0.64) and 0.61% (95% CI 0.32–0.90), respectively. Forty-one percent of the subjects had progression greater than the smallest detectable difference at 6 months.Conclusion. In this small cohort at high risk of OA progression, bone area changed at 3 and 6 months when cartilage morphometric measures did not.