RT Journal Article
SR Electronic
T1 Health State Utilities and Disease Duration in Systemic Sclerosis: Is There an Association?
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1832
OP 1837
DO 10.3899/jrheum.160162
VO 43
IS 10
A1 Adam J.N. Raymakers
A1 Nicole W. Tsao
A1 Carlo A. Marra
A1 Philip J. Clements
A1 Dinesh Khanna
YR 2016
UL http://www.jrheum.org/content/43/10/1832.abstract
AB Objective. Health state utility values (HSUV) are used as weightings to calculate quality-adjusted life years in economic evaluations. Evidence suggests that patients’ perceptions of a new diagnosis for a chronic disease, while initially poor, may improve over time. The objective of this study was to examine the association between disease duration and direct HSUV scores in patients with systemic sclerosis (SSc).Methods. Our study included patients with SSc from a US SSc center. An interviewer administered direct HSUV techniques including the visual analog scale (VAS), time tradeoff (TTO), and standard gamble (SG). We calculated the Short Form 6D HSUV from the Medical Outcomes Study Short Form-36. Additional clinical and demographic variables were collected.Results. The mean age of the SSc sample (n = 223) was 51 years (SD 16) with the majority being women (84%). Median disease duration was 5 years (interquartile range 1.5–9). Mean (SD) HSUV scores were 0.67 (0.19) for the VAS, 0.76 (0.28) for the TTO, 0.84 (0.22) for the SG, and 0.65 (0.13) for the SF-6D. In patients with early disease (defined as ≤ 2 yrs, n = 78), the mean HSUV values were 0.64 (VAS), 0.70 (TTO), 0.80 (SG), and 0.63 (SF-6D) versus for those with a longer disease duration: 0.69, 0.79, 0.87, and 0.67, respectively. In multivariate analysis, the SG measure showed a significant and positive association with disease duration measured as a continuous variable and using a threshold of 2 years (p = 0.047 and p = 0.023, respectively).Conclusion. Greater disease duration showed a positive association with a direct measure (SG) of utility elicitation after a period of 2 years.