RT Journal Article SR Electronic T1 The Role of High-resolution Peripheral Quantitative Computed Tomography as a Biomarker for Joint Damage in Inflammatory Arthritis JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 1911 OP 1913 DO 10.3899/jrheum.160645 VO 43 IS 10 A1 Lai-Shan Tam YR 2016 UL http://www.jrheum.org/content/43/10/1911.abstract AB Since 2011, members of the SPECTRA Collaboration (Study grouP for xtrEme-Computed Tomography in Rheumatoid Arthritis) have investigated the validity, reliability, and responsiveness of high-resolution peripheral quantitative computed tomography (HR-pQCT) as a biomarker for joint damage in inflammatory arthritis. Presented in this series of articles are a systematic review of HR-pQCT-related findings to date, a review of selected images of cortical and subchondral trabecular bone of metacarpophalangeal (MCP) joints, results of a consensus process to standardize the definition of erosions and their quantification, as well as an examination of the effect of joint flexion on width and volume assessment of the joint space.