PT - JOURNAL ARTICLE AU - Lai-Shan Tam TI - The Role of High-resolution Peripheral Quantitative Computed Tomography as a Biomarker for Joint Damage in Inflammatory Arthritis AID - 10.3899/jrheum.160645 DP - 2016 Oct 01 TA - The Journal of Rheumatology PG - 1911--1913 VI - 43 IP - 10 4099 - http://www.jrheum.org/content/43/10/1911.short 4100 - http://www.jrheum.org/content/43/10/1911.full SO - J Rheumatol2016 Oct 01; 43 AB - Since 2011, members of the SPECTRA Collaboration (Study grouP for xtrEme-Computed Tomography in Rheumatoid Arthritis) have investigated the validity, reliability, and responsiveness of high-resolution peripheral quantitative computed tomography (HR-pQCT) as a biomarker for joint damage in inflammatory arthritis. Presented in this series of articles are a systematic review of HR-pQCT-related findings to date, a review of selected images of cortical and subchondral trabecular bone of metacarpophalangeal (MCP) joints, results of a consensus process to standardize the definition of erosions and their quantification, as well as an examination of the effect of joint flexion on width and volume assessment of the joint space.