RT Journal Article
SR Electronic
T1 Analysis of Systemic Sclerosis-associated Genes in a Turkish Population
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1376
OP 1379
DO 10.3899/jrheum.160045
VO 43
IS 7
A1 F. David Carmona
A1 Ahmet Mesut Onat
A1 Tamara Fernández-Aranguren
A1 Alberto Serrano-Fernández
A1 Gema Robledo
A1 Haner Direskeneli
A1 Amr H. Sawalha
A1 Sule Yavuz
A1 Javier Martín
YR 2016
UL http://www.jrheum.org/content/43/7/1376.abstract
AB Objective. To evaluate the genetic background of systemic sclerosis (SSc) in the Turkish population.Methods. There were 354 cases and 718 unaffected controls from Turkey genotyped for the most relevant SSc genetic markers (IRF5-rs10488631, STAT4-rs3821236, CD247-rs2056626, DNASE1L3-rs35677470, IL12A-rs77583790, and ATG5-rs9373839). Association tests were conducted to identify possible associations.Results. Except for ATG5, all the analyzed genes showed either significant associations (IRF5: p = 1.32E–05, OR 1.76; CD247: p = 2.20E–03, OR 0.75) or trends of association (STAT4: p = 0.066, OR 1.21; IL12A: p = 0.079, OR 4.07; DNASE1L3: p = 0.097, OR 1.41) with the overall disease or with specific phenotypes.Conclusion. The genetic component of SSc seems to be similar between Turks and Europeans.